P. Andrews

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Peter Andrews is an Honorary Professor at the University of Edinburgh, from August 1, 2007. He has an international reputation in Neurological Intensive Care and has sustained an active, externally funded research programme for more than twenty five years. Research streams include; “Direct Brain Cooling” studies attracting external funding of over £350K and public recognition of the importance of this work. This work has lead to grant funding to develop non-invasive measurement of regional brain temperature using magnetic resonance spectroscopy.

Prof. Andrews was the Chief Investigator of the EUROTHERM3235Trial investigating the use of titrated (www.eurotherm3235trial.eu) hypothermia after traumatic brain injury in patients with raised intracranial pressure. This has attracted funding of £900K from the European Society of Intensive Care Medicine for the pilot phase and the National Institute for Health, Health Technology Assessment board recently (September 2012) awarded £2.18Million for main phase of the trial.

Prof Andrews was the Chief Investigator of the “SIGNET Trial” (RCT in Scottish Intensive Care Units). This was the first UK non-commercial multicentre CT-IMP trial in critical care and had funding of over £1.5M (including £1.1M from the MRC, UK).

Prof Andrews is chairman of the TOPSAT(2) DSMBs and a member of another 4 DSMBs. Prof Andrews is section head for Neurological-Intensive Care (Europe) at Faculty of Medicine 1000 (http://www.facultyof1000.com) and member of the Scottish Neuroscience Council.

Selected Publications (last 5 years):

Andrews PJD, Rodriguez A, Suter P, et al., Mortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235 Trial. Crit Care Med. 2017 May;45(5):883-890.

Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK, Murray GD; Eurotherm3235 Trial Collaborators. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med. 2015 Oct 7. PMID: 26444221

Flynn LM, Rhodes J, Andrews PJ. Therapeutic Hypothermia Reduces Intracranial Pressure and Partial Brain Oxygen Tension in Patients with Severe Traumatic Brain Injury: Preliminary Data from the Eurotherm3235 Trial. Ther Hypothermia Temp Manag. 2015 May 19. [Epub ahead of print]

Kilgour AH, Semple S, Marshall I, Andrews P, Andrew R, Walker BR. 11β-Hydroxysteroid dehydrogenase activity in brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men. J Clin Endocrinol Metab. 2014 Nov 13:jc20143277. [Epub ahead of print] PMID: 25393644

CALORIES Trial Investigators. Trial of the route of early nutritional support in critically ill adults. N Engl J Med. 2014 Oct 30;371(18):1673-84. doi: 10.1056/NEJMoa1409860. Epub 2014 Oct 1. PMID: 25271389 (as “Andrews P”)

Thrippleton MJ, Parikh J, Harris BA, Hammer SJ, Semple SI, Andrews PJ, Wardlaw JM, Marshall I. Reliability of MRSI brain temperature mapping at 1.5 and 3 T. NMR Biomed. 2013 Nov 24. doi: 10.1002/nbm.3050

Harris B, Andrews P, Murray G, Forbes J, Moseley O. Systematic review of head cooling in adults after traumatic brain injury and stroke. Health Technol Assess. 2012 Nov;16(45):1-175. doi: 10.3310/hta16450.

Andrews PJ, Avenell A, Noble DW, Campbell MK, Croal BL, Simpson WG, Vale LD, Battison CG, Jenkinson DJ, Cook JA; and the SIGNET (Scottish Intensive care Glutamine or seleNium Evaluative Trial) Trials Group. (2011) Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ. 2011 Mar 17;342:d1542. doi: 10.1136/bmj.d1542.